Systematic review and individual patient data meta-analysis on glucose- 6 – phosphate dehydrogenase activities measured by a semi-quantitative handheld biosensor

B Ley; LR Vasquez; A Sitsabasan; B Adhikari; N Adhikari; MS Alam; S Das; P Ghimire; MVG Lacerda; RN Price; KR Rijal; L von Seidlein; A Talukdar; K Thriemer; AW Satyagraha; A Sadhewa; M Rajasekhar; RJ Commons

Journal article

Systematic review and individual patient data meta-analysis on glucose- 6 – phosphate dehydrogenase activities measured by a semi-quantitative handheld biosensor

B Ley, LR Vasquez, A Sitsabasan, B Adhikari, N Adhikari, MS Alam, S Das, P Ghimire, MVG Lacerda, RN Price, KR Rijal, L von Seidlein, A Talukdar, K Thriemer, AW Satyagraha, A Sadhewa, M Rajasekhar, RJ Commons

Malaria Journal | Published : 2025

DOI: 10.1186/s12936-025-05654-6

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Abstract

Background: Measurement of glucose-6-phosphate dehydrogenase (G6PD) activity guides hypnozoitocidal treatment of P vivax malaria. The G6PD Standard (SDBiosensor, Republic of Korea) here referred to as “Biosensor” is a quantitative point-of-care diagnostic that measures G6PD activity in U/gHb. The manufacturer recommends cutoffs to define G6PD deficient (≤ 4.0U/gHb), intermediate (4.1- ≤ 6.0U/gHb) and normal (> 6.0U/gHb) individuals. The aim of this individual patient data (IPD) meta-analysis was to evaluate these cutoffs (CRD42023406595). Methods: A systematic review identified studies reporting population-level G6PD activity measured by Biosensor, published between January 2017 and May 2023..

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